Simon is a graduate of The George Washington University with a BS with Honors in Biological Sciences. Before entering UMassmed as an MD/PhD candidate, he conducted research at George Washington in the fields of physiology and transcriptomics in the lab of Dr. Randall Packer. He also investigated the innate immune function of tumors in the context of virotherapy while in the lab of Prof. Leonard Seymour at the University of Oxford.
His current interests surround targeted therapeutics for cancer including immunotherapy, virotherapy, and nucleotide therapeutics. He has finished rotations at UMass in the labs of Dr. Sam Behar on T-cell response to TB, Dr. Michael Brehm on humanized immune system mouse models, Dr. Wen Xue on genes conferring resistance to PD-1 blockade in hepatocellular carcinoma, and Dr. Miguel Esteves on anti-sense oligonucleotide targeting of diffuse infantile pontine glioma. In September 2020 he will be joining the Esteves lab continuing his work on treatment of pediatric glioma